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Saturday, October 19, 2013

AncestryDNA Autosomal DNA Analysis Version 2.0 and Problems Therewith

Ancestry.com's AncestryDNA still has problems. Ancestry.com is on Version 2.0, though, to be fair. Nonetheless, part of their methodology still includes counting "nations of the former Yugoslavia—Croatia, Bosnia and Herzegovina, Serbia, Montenegro, Kosovo, and Macedonia"—as part of Eastern Europe (Europe East). 

Also, they count European Jews as native to Europe—"The chart above (in blue) shows that the DNA of the typical person from the European Jewish region is very unique to this region. Most people from this region have very little (if any) DNA shared with neighboring regions. However there are some exceptions to this. When we estimate ethnicity for people from this region a small minority see results showing 65% of their DNA is similar to this region."

Their methodology also includes major problems—e.g., "The next step is to estimate a customer’s ethnicity based on the DNA of the reference set of individuals, as well as the DNA of the customer. We assume that an individual’s DNA is a mixture of DNA from a set of “source” reference populations." Their reference panel includes "a candidate set of 4,245 individuals."


That's not even 0.0001% of the global population. (Divide 6,000 by 6,000,000,000,000 to get this number.). They say at the end, nonetheless, that they are improving that. "Currently, we are working to even further expand our global reference panel for future ethnicity updates. We have already begun genotyping and analyzing samples for a future update which will provide finer-grained estimates of ethnicity."

However, they did seem to confirm what I was saying about us being Jewish (Also count that other Jews have had problems being noted as Jewish by AncestryDNA), and that we may have had possible Sephardic ancestry:



By the way, "Palestine" (Israel) is erroneously counted as part of the "Caucusus". So are Iran, Iraq, and Syria. Google "AncestryDNA European Jews" and "AncestryDNA Ashkenazi Jews", by the way: you will see that other Ashkenazi Jews are having problems with AncestryDNA. Also, they continue not to match my dad up with a Fosko third cousin and a Margevich cousin:


  • [Margevich Cousin]
  •  Possible range: 5th - 8th cousins
  •  
    Confidence: Moderate
  • Last logged in Oct 6, 2013
 41 people



  • [Fosko cousin]
  •  Possible range: 5th - 8th cousins
  •  
    Confidence: Low
  • Last logged in Oct 6, 2013
 1764 people 


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